HPC MSU
Name:Mariola J Edelmann
Associated Centers:Institute for Genomics, Biocomputing and Biotechnology
Position:Faculty
Email: MEdelmann@mafes.msstate.edu
Office:Pace Seed Lab, 120
Office Phone:(662) 325-7611
Address:650 Stone Blvd.
Mississippi State
MS 39762

Biography:I started my research experience in the field of ubiquitin proteasome system and proteomics in the Wellcome Trust Centre for Human Genetics, Oxford University, UK. I worked at Oxford University as a research assistant in mass spectrometry and protein biochemistry for over four years.

I also completed my Ph.D. in Clinical Medicine at Oxford University, with my research interests being focused on protein deubiquitination, protein mass spectrometry and host-pathogen interactions.

I worked as a research assistant professor at the Institute for Genomics, Biocomputing and Biotechnology (IGBB) in years 2010-2013, and at the moment I am an assistant professor at the Basic Science Department at the College of Veterinary Medicine, MSU.

My NIH-funded research primarily relates to the molecular aspects of the host-pathogen interactions during bacterial infections (Yersinia, Shigella, Salmonella). I am also interested in mass spectrometry-based proteomics, for instance finding new methods to quantify post-translational modifications and utilizing chemical biology methods to quantify and annotate enzymes.

Research Interest: - protein turnover and ubiquitin proteasome system
- host-pathogen interactions (type three secretion bacteria: Salmonella, Shigella, Yersinia)
- protein post-translational modifications (ubiquitination, phosphorylation, acetylation, methylation etc.) and their impact on protein function
- proteomics



Publications: Edelmann, M. J., Nallamilli, B. R., Zhong, X., Tan, F., Mujahid, H., Zhang, J., Nanduri, B., & Peng, Z. (2014). Global Analysis of Lysine Acetylation Suggests the Involvement of Protein Acetylation in Diverse Biological Processes in Rice (Oryza Sativa). PlosOne. 9(2), e89283.

Glinka, T., Alter, J., Braunstein, I., Tzach, L., Sheng, C. W., Geifman, S., Edelmann, M. J., Kessler, B., & Stanhill, A. (2014). Signal-peptide Mediated Translocation Is Regulated by a P97-AIRAPL Complex. Biochemical Journal. 1, 1-1. DOI:10.1042/BJ20130710. [Abstract] [Document Site]

Edelmann, M. J., Kramer, H. B., & Kessler, B. M. (2010). Post-translational Modification of the Deubiquitinating Enzyme Otubain 1 Modulates Active RhoA Levels and Susceptibility to Yersinia Invasion. FEBS Journal. 277(11), 2515 2530. [Document Site]

Mortensen, M., Ferguson, D. J., Edelmann, M. J., Kessler, B., Morten, K. J., Komatsu, M., & Simon, A. K. (2010). Loss of Autophagy in Erythroid Cells Leads to Defective Removal of Mitochondria and Severe Anemia in Vivo. PNAS. 107(2), 832-7. [Document Site]

Edelmann, M. J., Iphöfer, A., Akutsu, M., Altun, M., DiGleria, K., Kramer, H. B., Fiebiger, E., Dhe-Paganon, S., & Kessler, B. M. (2009). Structural Basis and Specificity of Human Otubain 1-mediated Deubiquitination. Biochemistry Journal. 418(2), 379-90. [Document Site]

Total Publications by this Author: 43