|Biography:||I started my research experience in the field of ubiquitin proteasome system and proteomics in the Wellcome Trust Centre for Human Genetics, Oxford University, UK. I worked at Oxford University as a research assistant in mass spectrometry and protein biochemistry for over four years. |
I also completed my Ph.D. in Clinical Medicine at Oxford University, with my research interests being focused on protein deubiquitination, protein mass spectrometry and host-pathogen interactions.
My research primarily relates to the molecular aspects of the host-pathogen interactions during bacterial infections (Yersinia and Salmonella) and inflammation. I am also interested in mass spectrometry-based proteomics, for instance finding new methods to quantify post-translational modifications and utilizing chemical biology methods to quantify and annotate enzymes.
|Research Interest: ||- protein turnover and ubiquitin proteasome system|
- host-pathogen interactions (type three secretion bacteria: Salmonella, Yersinia)
- protein post-translational modifications (ubiquitination, phosphorylation, acetylation, methylation etc.) and their impact on protein function
|Publications: ||Alugubelly, N., Hercik, K., Kibler, P., Nanduri, B., & Edelmann, M. J. (2016). Analysis of Differentially Expressed Proteins in Yersinia Enterocolitica-infected HeLa Cells. BBA - Proteins and Proteomics. 1864(5), 562-569. [Document Site]|
Kummari, E., Alugubelly, N., Hsu, C., Dong, B., Nanduri, B., & Edelmann, M. J. (2015). Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation. PLOS ONE. PLOS. 1, 1-10. DOI:10.1371/journal.pone.0135531. [Document Site]
Edelmann, M. J., Shack, L. B., Naske, C. D., Walters, K. B., & Nanduri, B. (2014). SILAC-Based Quantitative Proteomic Analysis of Human Lung Cell Response to Copper Oxide Nanoparticles. PLOS ONE. 9(12), e114390. DOI:10.1371/journal.pone.0114390. [Document Site]
Mortensen, M., Ferguson, D. J., Edelmann, M. J., Kessler, B., Morten, K. J., Komatsu, M., & Simon, A. K. (2010). Loss of Autophagy in Erythroid Cells Leads to Defective Removal of Mitochondria and Severe Anemia in Vivo. PNAS. 107(2), 832-7. [Document Site]
Edelmann, M. J., Iphöfer, A., Akutsu, M., Altun, M., DiGleria, K., Kramer, H. B., Fiebiger, E., Dhe-Paganon, S., & Kessler, B. M. (2009). Structural Basis and Specificity of Human Otubain 1-mediated Deubiquitination. Biochemistry Journal. 418(2), 379-90. [Document Site]
|Total Publications by this Author: 47|